Radiosensitizing Effects of Herbal Compounds in Cervical Cancer: A Systematic Review

Abstract

Introduction: Radiotherapy is a primary treatment for cervical cancer, but radioresistance remains a major challenge. Certain herbal compounds have been shown to act as radiosensitizers, enhancing the efficacy of radiation. This review summarizes the evidence for these compounds in cervical cancer models.

Methods: A systematic search of preclinical studies was conducted. We included in-vitro and in-vivo studies that assessed the ability of herbal compounds (e.g., curcumin, ginsenosides, resveratrol) to enhance the cell-killing effects of ionizing radiation on cervical cancer cells.

Results: The review included 22 studies. Curcumin, ginsenoside Rg3, and resveratrol were the most studied compounds. They consistently demonstrated radiosensitizing effects by inhibiting DNA repair mechanisms in cancer cells, promoting radiation-induced apoptosis, and suppressing the activation of pro-survival pathways like NF-κB.

Discussion: Multiple herbal compounds can effectively sensitize cervical cancer cells to radiation, potentially allowing for lower radiation doses or overcoming resistance. This represents a promising strategy to improve therapeutic outcomes.

Conclusion: Several herbal compounds are potent radiosensitizers in preclinical models of cervical cancer.