Correlation of Haemoglobin Platelet Ratio (HPR) and LeukocytePlatelet Ratio (LPR) with SYNTAX-2 Score in STEMI Patients

Abstract

Introduction

In patients with ST-segment elevation myocardial infarction (STEMI), easily accessible hematological ratios are emerging as significant prognostic markers for risk stratification. These simple blood-derived ratios reflect underlying inflammatory and thrombotic states critical to STEMI pathophysiology. This review synthesizes literature on the correlation between ratios like the Haemoglobin Platelet Ratio (HPR) and Leukocyte-Platelet Ratio (LPR) with the SYNTAX-2 score, a tool for assessing coronary lesion complexity and guiding treatment.

Methods

This abstract is based on a literature review synthesizing findings from multiple clinical studies. The review examined the prognostic value of various hematological ratios—including HPR, LPR, Platelet-to-Lymphocyte Ratio (PLR), and Neutrophil-to-Lymphocyte Ratio (NLR)—in predicting clinical outcomes, procedural complications, and the severity of coronary artery disease in STEMI patients.

Results

The literature consistently demonstrates that hematological ratios are significant prognostic markers in STEMI. Elevated PLR and NLR are independent predictors of adverse cardiovascular events, including in-hospital mortality. Specifically, HPR and LPR have been correlated with the SYNTAX-2 score, suggesting their value in assessing the complexity of coronary lesions. Furthermore, LPR has been associated with an increased risk of in-hospital major bleeding events, especially in patients with low platelet reactivity.

Discussion

The evidence strongly supports the use of these simple, cost-effective hematological markers for risk stratification in STEMI patients. These ratios provide a window into the systemic inflammatory and thrombotic milieu that drives acute coronary syndromes. Their correlation with the SYNTAX score establishes a valuable link between systemic inflammation and the anatomical complexity of coronary disease, offering clinicians an accessible tool that complements traditional risk factors for enhanced decision-making.

Conclusion

Hematological ratios, including HPR and LPR, are valuable and accessible prognostic markers in patients with STEMI. Their correlation with the SYNTAX-2 score and clinical outcomes underscores their potential to enhance risk stratification and guide management strategies. The integration of these markers into clinical protocols could lead to more tailored and effective patient care.